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News News Blog

UTHSC Chair Awarded $1.85 Million Grant to Continue Research of Alcohol Effects on the Brain

Dr. Alex Dopico

  • Dr. Alex Dopico

Enjoying a cocktail or two won’t kill you, but over-consumption of alcoholic beverages isn’t good for one’s health.

For more than 20 years, Dr. Alex Dopico, professor and chair of the University of Tennessee Health Science Center’s (UTHSC) Department of Pharmacology, has researched alcohol’s effects on ion channel proteins in the central nervous system and brain circulation.

In 2009, Dopico was awarded a $3.6 million Method to Extend Research in Time (MERIT) Award from the National Institute on Alcohol Abuse and Alcoholism. Dopico was permitted to use the award over a 10-year period for his alcohol studies, which involves him researching the effects of alcohol on BK channels in excitable cells, such as central neurons and brain arterial smooth muscle.

The first half of Dopico’s MERIT Award expired this past June. He was recently awarded a $1.85 million extension to fund the remaining five years of his research. With the additional funding, Dopico seeks to develop drugs that target the proteins within cells that control the physiological and behavioral changes associated with alcohol intoxication in order to prevent or reverse those effects, according to a UTHSC press release.

“My job is to find molecular sites and mechanisms by which alcohol affects excitable tissue physiology, and thus agents that fight the consequences of alcohol intoxication in the brain,” Dopico said in a statement. “To do that, you need to find the protein sites where alcohol docks or interacts, and we had a very critical breakthrough in the BK channel protein.”

Excessive alcohol use led to approximately 88,000 deaths and 2.5 million years of potential life lost each year in the United States from 2006 to 2010, according to the Centers for Disease Control and Prevention. Also, excessive drinking was responsible for one in 10 deaths among adults aged 20 — 64 years. The economic costs of excessive alcohol consumption in 2006 were estimated at $223.5 billion, or $1.90 a drink.

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Sing All Kinds We Recommend

Kiwi-Pop Primer

To get you excited for The Clean playing the Hi-Tone tonight, here’s a video playlist of some of their earliest videos, along with some other great hits from the golden age of Flying Nun records.

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News

Memphis Police Department Resists Militarization Trend

The MPD hasn’t gotten much military equipment from the feds, and Mayor AC Wharton says he prefers it that way. Toby Sells reports.

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Sing All Kinds We Recommend

Summer Movie Journal #6

1941 (1979; dir. Steven Spielberg)—Hollywood will not rest until every inspirational story from World War II becomes a hand-over-heart ode to the Greatest Generation. Brad Pitt plays Sergeant Wardaddy—oh, come on—in Fury, which comes out in October; Angelina Jolie directed Unbroken, an “inspiring true story” about WWII prison camps which opens on Christmas Day. In this context, Steven Spielberg’s self-proclaimed “blast in the face” about the night the Japs tried to invade southern California is, if anything, even more vital and necessary. Spielberg and his co-conspirators (among them Robert Zemeckis, John Milius, and anyone who happened to drop by the set) put everything they had into this hyperactive, all-ages demolition derby, and their work shows: it never settles down and never lets up. Nothing is safe; everything is demolished. Among the casualties are the Hollywoodland sign, the USO, the concept of military intelligence, the concept of female virtue, many huge vats of paint, Christmas cheer, the fantasy of living a quiet life in the suburbs and the sanctity of a morning skinny-dip in the Pacific Ocean. It’s infantile, lewd, sticky, gross, and popping with nasty urges; Nancy Allen’s J.G. Ballard-like airplane fetish is maybe the third-kinkiest thing here. And gol-lee, how about that cast: John Belushi, Dan Aykroyd, John Candy, Robert Stack, Toshiro Mifune (who, naturally, speaks only Japanese), Christopher Lee (who, unnaturally, speaks only German), Slim Pickens, and Samuel Fuller, plus a dozen other major and minor cameos. (Three of the four leads in Laverne & Shirley? Mickey Rourke???) I found it an unfunny mess, but I also found it a fascinating free-for-all and a heartwarming piece of civil disobedience that would warm Thomas Jefferson’s heart. Upped a notch for chutzpah. Grade: A-


Get On Up
(2014; dir. Tate Taylor)— In his magnificent and perceptive 2006 Rolling Stone profile “Being James Brown”, Jonathan Lethem made the following claim: “James Brown is, like Billy Pilgrim in Kurt Vonnegut’s Slaughterhouse-Five, a man unstuck in time. He’s a time traveler, but unlike the HG Wells-ian variety, he lacks any control over his migrations in time, which also seem to be circumscribed to the period of his own allotted lifespan. Indeed, it may be the case that James Brown is often confused as to what moment in time he occupies at any given moment.” This wildly original sci-fi thesis informs Tate Taylor’s superb new Brown biopic, which conceives of the Godfather of Soul’s life as an endless groove where the needle can be picked up and dropped at random. The jumbled chronology and gallery of James Browns striding through the film only adds to the legend; after seeing Get On Up, I went back to RJ Smith’s biography The One to confirm some details. Did Bobby Byrd really spring Brown from prison and bring him home? (Yes.) Did Little Richard really flirt with Brown at a hamburger stand one night and tell him about the white devils running the music industry? (Probably.) Did a pre-teen Brown win a “battle royale” straight out of Invisible Man? (Yes.) Did he hear the strains of “Cold Sweat” as he did so? (Maybe. Time travel, remember.)As Brown, Chadwick Boseman is sensational—he’s funny without being a parody, and his lip-synching feels like the real thing. His James Brown is electrifying, seductive, materialistic, mythic. And scary, too; watch Boseman look straight into the camera at you after he decks his wife on Christmas Day. Then try to deny Brown’s place at the forefront of pop music today. It can’t be done, because James Brown is history. Let the record show that, to my surprise, I found Get On Up superior to Boyhood in pretty much every way. Grade: A-


The Trip
(2010; dir. Michael Winterbottom)—In this semi-authentic travel documentary, actor/comedian Steve Coogan and actor/comedian Rob Brydon travel around northern England, eat fine cuisine, and try to make each other laugh. There’s a little more to it, of course, but not much; Coogan cheats on his American girlfriend twice and falls into a stream, while Brydon quotes Wordsworth in a Scottish accent and tries to talk his wife into phone sex. Will you like it? Depends on how intrigued you are by the prospect of dueling Michael Caine impressions. Civilians like me imagine that this is how professional funny people interact, and it’s simultaneously hilarious and exhausting to watch them engage in endless, irritating, look-at-me riffing that doesn’t stop until someone either laughs or leaves the table. But watching Coogan and Brydon critique each other’s attempts to sound like Sean Connery and Roger Moore, or listening to them as they endlessly repeat the Goldfinger line “Come, come, Mr. Bond, you derive just as much pleasure from killing as I do” is something, like the Lake District, that must be experienced first-hand. Mere words fail me. The sequel, The Trip to Italy, arrives in select cities—like mine—this Friday. Grade: A-


Katzelmacher (1969; dir. Rainer Werner Fassbinder)—Of the dozens of films Fassbinder cranked out before his untimely death in 1982 at age 37, I’ve only seen a handful. But I’ve never been disappointed by his infectious tawdriness and sadistic stylistic voluptuousness; movies like Martha and The Marriage of Maria Braun are not soon forgotten. Katzelmacher, Fassbinder’s second feature, is about working-class belligerence, fear and boredom in a drab, desolate Munich apartment complex. Apparently, in the days before cell phones, people who couldn’t afford to entertain themselves or smoke cigarettes all day squatted outside their apartment, swapped gossip and lies, and beat up foreigners before returning to their hovels for some brutally clinical sex. The actors look worn down to their gums by whatever it is they do for a living off-camera, and the camera is almost entirely motionless; like the characters, it can’t seem to go anywhere or get out of its narrow rut. Grade: A-

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Politics Politics Beat Blog

State AG Cooper Stipulates the Rules for Filling Senate Vacancy

State Attorney General Robert Cooper

[AMENDED AND UPDATED] Definitive word has finally come down as to how the party nominations for state Senate District 30, to succeed Chancellor-elect Jim Kyle, must be conducted. Tennessee Attorney General Robert Cooper has delivered an opinion that would:

(1) require nominations to be made by the two major parties’ local governing bodies — the Shelby County Democratic executive committee and the Shelby County Republican steering committee;

(2) limit the number of eligible voters to those committee members who represent precincts that lie within Senate District 30.

In the case of Democrats, who elect most of their executive committee members by House District, this effectively franchises all members representing House Districts which contain such precincts.

Republicans also elect many of their steering committee members from House Districts, but a majority of their committee members are at-large and will also be enabled to vote.

(3) require House members seeking the Senate nomination to withdraw from the November ballot before attempting to win their party’s nomination for the Senate. This requirement places a clear burden upon rumored candidates like Democratic state Reps. Antonio Parkinson and G.A. Hardaway, inasmuch as the withdrawal of either from the November ballot would necessitate a write-in campaign to fill the ballot void for their party’s House race.

Preliminary word is that the county’s Democratic committee will be asked by chairman Bryan Carson to convene on September 8 to name a candidate.

All candidacies, whether by party nomination or by independents, must be certified by a date 45 days from the date of the November 4 election. That would seem to make the September 20 the effective deadline for application to the Election Commission.

Further relevant details will be posted as they are learned. Meanwhile, the full opinion of Attorney General Cooper may be accessed here: [pdf-1]

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Sing All Kinds We Recommend

Al Bell To Introduce WATTSTAX at the Shell Friday

Indie Memphis‘ concert film series plays host to Stax co-owner Al Bell, who will introduce and discuss the origin of the musical documentary film WATTSTAX. The film captures the Stax roster at the height of the label’s success during a 1972 concert at the Los Angeles Memorial Coliseum. The opening sequence strikes you immediately in light of recent events in Ferguson. Richard Pryor’s monologues are disturbingly prescient. Bell organized the festival that Mel Stuart captured in the 1973 film. Al Bell’s remarks will be a Memphis history lesson. The music makes you move, and the dialog makes you squirm and think. It’s the funkiest lesson in civic morality in the history of humanity. Friday, August 29th, at 8 p.m.

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Sports Tiger Blue

“American” Football Picks: Week 1

The aim is a simple one: improve on last season’s record of 57-23. Seventy-one percent may be good enough in some corners of cyberspace, but not here. Away we go . . . .

AAC_logo.jpg

THURSDAY
Tulane at Tulsa
Temple at Vanderbilt

FRIDAY
Texas-San Antonio at Houston
BYU at UConn

SATURDAY
Austin Peay at Memphis
North Carolina Central at East Carolina
Western Carolina at USF
Penn State vs. UCF (in Ireland)

SUNDAY
SMU at Baylor

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Opinion Viewpoint

Deforming Tennessee Justice

A Tennessee “country lawyer” named Andrew Jackson founded the Democratic Party. An Illinois “prairie lawyer” named Abraham Lincoln founded the Republican Party. Both represented people charged with violent crimes. Jackson allegedly committed a few of his own in his early years, and Lincoln was defending people charged with murder, right up to the time of his run for the presidency.  

Lincoln’s memorial now stands on our national mall in Washington, D.C., as both a tribute to justice and the most visible platform for those seeking fairness to peaceably assemble. Many of our founding fathers were defense attorneys. John Adams even defended the British soldiers at the Boston massacre. But today, the voices of private criminal defense lawyers are not wanted nor welcomed by the state government in Nashville. Somehow, American heroes like Thurgood Marshall and the fictional Atticus Finch are no longer valued as part of American culture.

Last week, Governor Bill Haslam formed a 27-member task force to reform sentencing laws in Tennessee. The goal is a noble one, as nearly every study of prisons reveals that the United States has 5 percent of the world’s population, but more than 25 percent of the world’s prison population. Recent events in Ferguson, Missouri, demonstrate the anger that many citizens have at a government that is over militarized and increasingly appears to be waging war on its own people. 

Citizens of Tennessee can likely expect more of the same from the sentencing task force. The commission counts numerous prosecutors, judges, and police chiefs among its membership, and gives the appearance of being well rounded. However, the task force lacks even one private criminal defense lawyer among its members. In fact, the governor appointed only one recently reelected public defender to the task force. In other words, almost no one charged with “reforming” sentencing in a draconian justice system has ever defended a citizen at a sentencing hearing.  

The act of standing alone with a single citizen as the overwhelming weight of our government crushes his liberty is an experience that almost no one on the task force understands. The government will reform itself largely on the advice of its own employees, and without the advice of those independent thinkers who exist outside of government — like the lawyers who founded our country.

Six Shelby County residents were appointed to the task force. All are white Republicans, now tasked with reforming a system that overwhelmingly affects people of color. But, more importantly, none have defended a sentencing hearing since these laws were created in 1994.  

Senator Brian Kelsey is a lawyer who has never argued a case in criminal court. Sheriff Bill Oldham is not a lawyer, but his son serves as a prosecutor in the criminal courts. His predecessor in the Sheriff’s Office is Mark Luttrell, our current county mayor, who never argued a criminal case. Bill Gibbons is the current director of Tennessee’s Department of Homeland Security, a law enforcement position. As a lawyer, he served as our district attorney in an administrative capacity and never argued a criminal case.  

Amy Weirich is one of the most accomplished trial attorneys in the history of Shelby County, but has served only in the role of prosecutor. The Honorable John Campbell is equally accomplished as a trial lawyer, having served as a prosecutor from 1986 until he took the bench in 2012. A notable local lawyer who differs from all others on the committee in both appearance and work history but was not selected is Memphis Mayor A C Wharton.

I know several of these citizens, but my affection for them does not change the fact that each of them presents only one side of the debate about sentencing in Shelby County. For example, our laws send people to prison for six years for possessing $40 worth of marijuana, an act that is no longer a crime in several states. Possessing just $10 of cocaine can lead to a 30-year sentence.  

The elected officials of the task force all promise to be “tough” on crime. None ran advertisements promising to be “fair” or “smart” on crime. But the truth, the whole truth, and nothing but the truth is that families in Shelby County are destroyed by many of our sentencing laws. How can a commission this one-sided and completely lacking in practical perspective make any meaningful reform? 

The task force should remember the words of Lincoln: “A law may be both constitutional and expedient, and yet may be administered in an unjust and unfair way.” It would be even better for Tennessee if the task force had members who actually live and work as Lincoln did — to remind the group in person.

Mike Working is the owner of The Working Law Firm, and serves as a member of the board of directors for the Tennessee Association of Criminal Defense Lawyers.

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Music Music Features

John Hampton Recalls Gin Blossoms’ Success

The Gin Blossoms and Collective Soul play Bluesville at Horseshoe Casino Tunica on Saturday, August 30th. Memphis producer-engineer John Hampton worked with the Gin Blossoms on a string of hits in the 1990s.

In 1989, I was working on a band named Tora Tora with Brian Huttenhower from A&M records. Their second LP, Wild America, never quite got off the ground like we had hoped. The truth of the matter was that Tora was perceived as a “hair band.” And, with the flaming intro of Nirvana, a new music scene was emerging. Soon after 1991, a new slice of what I call “Pop-Rock” entered the mix in the form of the band Gin Blossoms. These guys were not heavy like Nirvana or Soundgarden. Their rather melancholy songs and well-crafted melodies, written by Doug Hopkins, Jesse Valenzuela, and Robin Wilson, along with classic pop music production, became music to which any teen ever damaged by love could relate. Huttenhower hired Arthur Payson (Ratt, Desmond Child) to finish Tora’s last two songs and sent me to Tempe, Arizona, to begin on a record with Gin Blossoms. Their semi-pro self-release (a common phrase today) “Dusted” from the late ’80s had caught Huttenhower’s ear.

My first trip to Phoenix was around the spring of ’91. The second we met, it became obvious that we would get along: They loved drinking beer and playing music around Tempe. After a few days, we started working on a record based on “Dusted,” and we began production on New Miserable Experience, a title I thought was fitting given their “Go For It and Fail” attitude. We cut the record with the band playing live, a few overdubs of harmony vocals, fixing individual instrument clams, and just a pinch of beefing up their slightly timid sound. I was able to create a modern sound, some call “jangle rock”: having a clean element fused with a rowdy element. Meaning if I had two clean guitar sounds, I would screw one up with distortion. Jesse was the jangle, and Doug was … harsh. These two elements of fire and ice can be heard on many hit records, my favorite example of which being the acerbic edge of John Lennon fused with the cloying anti-edge of Paul McCartney.

So we finished New Miserable UNDER the already-too-low budget for those days: I think we only had about $65,000. Considering Tora Tora’s budgets, this was a drop in a bucket. Upon its release, the Blossoms spent 15 months on the road. When they were in a region of the U.S., they became immensely popular in that region, but it would wane when they got to the next region. And the same thing would happen again. They would be hot in the southwest, then in the northwest, as the southwest cooled. This happened in every region of the country, but never all at once.

So, as A&M contemplated pulling the plug on New Miserable, they decided to go one more mile. It was a pretty risky mile: They pulled the band off the road, repackaged the record with new artwork, made a new video for “Hey Jealousy,” and, with one giant promotional push, reintroduced the Gin Blossoms to the country 15 months later — almost as if they had never been released!

This time it worked. Out of the box, the record sold 500,000 copies, and we all started seeing a bit of financial reward. Since it seemed to be at its peak of sales from the first single about one week before Christmas, we all enjoyed massive sales through the holiday season. And that was just from the first single. I thought we had five singles, so as each high-sales period waned, the record company would release another single, and another, and another. And it kept the record in the top 50 albums for nearly a year.

After that, the Gin Blossoms were becoming a household name. Their singles, “Hey Jealousy,” “Found Out About You,” “Mrs. Rita,” “Allison Road,” and “Until I Fall Away” were the five singles that kept them on top. With this new popularity, and as we prepared to try it again for a second record, the band was approached to do a song for the soundtrack of a movie entitled Empire Records. This resulted in “Til I Hear It From You” written by Jesse with Master of Melody, Marshall Crenshaw. That gave the world a late, sixth single. “Til I Hear It from You” not only sold the Empire soundtrack record, but it reinvigorated sales of New Miserable. Now we’re talkin’. There was money EVERYWHERE!! And we were so fired up about the second record’s sales with the inclusion of “Til I Hear It,” we thought it was going to be huge. But it seems true that for every action there is an equal and opposite reaction.

First, my good friend and the band’s guitar player and key songwriter writer, Doug, killed himself right before Christmas of ’93, which weighed heavily on us all. Doug really was the miserable guy. Alcohol and depression had just overwhelmed him, not to mention the fact that the band had been forced to fire him. The label’s concern about having a dysfunctional band member on tour had ultimately led to their finding a replacement for Doug.

Next was the news that we could not have “Til I Hear It From You” for record two because the label that released the Empire Records soundtrack was justifiably concerned that the A&M sales might dwarf their soundtrack record sales.

And finally, I was introduced to a profound concept relating to songwriting: A songwriter puts together songs from his or her entire life — some may be 10 years old, written at a time when there was zero pressure to write songs. Now, we were expected to equal or beat the songs from the first album. But if one takes an artist and puts him on the road for a 15-month tour, and shortly thereafter for another, larger 15-month tour, and you add the fact that all of the money coming in kind of relaxes the old anxiety of youth, you now have a MAJOR song problem.

So, the band starts down the path of record two with some good songs, but not quite the songs of youth. Though the second record has gone on to sell somewhere between 2 million to 3 million copies and is still selling today. After the second record, the final blow came that ended this chapter hit. Robin announced that, because his original place in the band was as a mouthpiece for Doug’s songs, he felt his work with the Gin Blossoms had served its purpose and that it was time for him to move on. (I could have strangled him right through the phone wires.) And that was that.

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Book Features Books

Jay Schoenberger’s Great Outdoors

Jay Schoenberger, who lives today in San Francisco, didn’t grow up hiking the Sierra Nevada. In grade school, then in high school at Memphis University School, he stayed closer to home: Shelby Farms, the Mississippi and Wolf rivers, east Arkansas, and north Mississippi.

As a student at Vanderbilt, he started mountaineering in East Tennessee. But after college (and before graduate school at Stanford), Schoenberger headed to Wyoming to participate in the National Outdoor Leadership School. It’s where he gained some solid wilderness training, and it’s where he realized his life’s work: preserving the natural environment. Inside his backpack during all these years was a loose-leaf stack of noteworthy wilderness writings meant to inspire and designed to share.

Jay Schoenberger

I Am Coyote: Readings for the Wild (foreword by Bill McKibben; illustrations by Peter Arkle) is Schoenberger’s collection of those scattered writings, and among the authors, you’ll find Henry David Thoreau, Herman Melville, John Darwin, Walt Whitman, Elizabeth Gilbert, Mark Twain, Robert Frost, and Edward Abbey. But there are surprises here as well: among them, Albert Camus, Fyodor Dostoevsky, and, from our own neck of the woods, Mississippi River guide John Ruskey.

Schoenberger, who works for a group that invests in wind energy development, calls I Am Coyote his “passion project.”

“I’ve been kicking the idea around for a while,” Schoenberger said. “And what really initiated the book was when I started going to outdoors shops looking to replace my loose collection of papers. But the books I found weren’t what I was looking for. I found books about male bravado, of proving yourself on adventures. Other books described the beauty of nature, but there was no compendium of the great wilderness writings — writings that friends and members of the outdoors community could take with them on their journeys. I could have compiled the works of John Muir or an anthology of the works of the transcendentalists, but nothing for this specific audience. So I did it myself.

“The book is not intended to be man-sees-mountain-and-climbs-it. It’s about not only nature and the variety to be found there but a lot of things that are related to the wilderness: reflection, meditation, and general awareness. But what resonates first and foremost throughout the book is a focus on people living vigorously and authentically — people deeply engrossed in the experience, immersed in it, grappling with all that that experience entails, including the joys and the struggles.”

The book is divided into five parts and consists of fiction and nonfiction, poetry and essays: from pieces that describe the excitement of setting out, to the awe and tranquility that nature inspires, to descriptions of the great outdoors at its most powerful and punishing, to nature as a means to self-discovery, to nature in need of preserving. Among the classics included, there’s “To Build a Fire” by Jack London, one of those stories, Schoenberger said, “you kind of remember forever” and a favorite among backpackers to read at the end of a long day.

But the piece in I Am Coyote perhaps closest to Schoenberger is Wallace Stegner’s powerful, eloquent argument for conservation, an essay Stegner presented to the Outdoor Recreation Resources Review Commission in 1960: “Wilderness Letter.” It’s a document Schoenberger first read when he was in Wyoming and one he always kept in his backpack. It’s also a landmark document, written in 1960, that was key to establishing the Wilderness Act, which has its 50th anniversary this year.

Schoenberger wants Memphians, especially, to look locally: to recognize — and respect — the nature preserves and wilderness around them. Shelby Farms, for example, he called “a treasure.” And the river at the city’s doorstep?

“A lot of people grow up thinking of the wilderness as the Rocky Mountains or Glacier National Park,” Schoenberger said. “But there’s a fantastic wilderness right in the middle of the country. When you’re out there on the Mississippi River, north or south of Memphis, it’s basically you and passing barges and tugboats and some guys fishing. It’s still pretty much wilderness, and that makes it a remarkable thing.”